List of Diseases AD: Alzheimer's Disease ADPD: Alzheimer's Disease and Parkinsons's Disease AMDF: Ataxia, Myoclonus and Deafness CIPO: Chronic Intestinal Pseudoobstruction with myopathy and Ophthalmoplegia CPEO: Chronic Progressive External Ophthalmoplegia DEAF: Maternally inherited DEAFness or aminoglycoside-induced DEAFness DEMCHO: Dementia and Chorea DMDF: Diabetes Mellitus & DeaFness Exercise Intolerance ESOC: Epilepsy, Strokes, Optic atrophy, & Cognitive decline FBSN: Familial Bilateral Striatal Necrosis FICP:: Fatal Infantile Cardiomyopathy Plus, a MELAS-associated cardiomyopathy GER: Gastrointestinal Reflux KSS Kearns Sayre Syndrome LDYT: Leber's hereditary optic neuropathy and DYsTonia LHON: Leber Hereditary Optic Neuropathy LIMM: Lethal Infantile Mitochondrial Myopathy MDM: Myopathy and Diabetes Mellitus MELAS:: Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes MEPR: Myoclonic Epilepsy and Psychomotor Regression MERME: MERRF/MELAS overlap disease MERRF: Myoclonic Epilepsy and Ragged Red Muscle Fibers MHCM: Maternally Inherited Hypertrophic CardioMyopathy MICM: Maternally Inherited Cardiomyopathy MILS: Maternally Inherited Leigh Syndrome Mitochondrial Encephalocardiomyopathy Mitochondrial Encephalomyopathy MM: Mitochondrial Myopathy MMC: Maternal Myopathy and Cardiomyopathy Multisystem Mitochondrial Disorder (myopathy, encephalopathy, blindness, hearing loss, peripheral neuropathy) NARP:: Neurogenic muscle weakness, Ataxia, and Retinitis Pigmentosa; alternate phenotype at this locus is reported as Leigh Disease NIDDM:: Non-Insulin Dependent Diabetes Mellitus PEM: Progressive Encephalopathy PME: Progressive Myoclonus Epilepsy RTT: Rett Syndrome SIDS: Sudden Infant Death Syndrome SNHL: Sensorineural Hearing Loss Varied Familial Presentation: clinical manifestations range from spastic paraparesis to multisystem progressive disorder & fatal cardiomyopathy to truncal ataxia, dysarthria, severe hearing loss, mental regression, ptosis, ophthalmoparesis, distal cyclones, & diabetes mellitus.